Baxdrostat’s lasting effect on high blood pressure is under study

Health · First reported 7 Nov, 14:35 · Updated 14:40

Image: Wikimedia Commons · Fikkar Bonggi · CC BY-SA 4.0

A small follow-up study found that some patients’ blood pressure remained lower for up to two years after stopping baxdrostat, a drug that suppresses aldosterone. Researchers say a larger study is needed to establish whether the effect is a lasting cure for hypertension linked to adrenal overproduction of the hormone.

Fourteen patients whose blood pressure improved during an initial trial continued baxdrostat for six to 12 months, then stopped; follow-up found their blood pressure remained lower for up to two years.
The drug suppresses aldosterone, a hormone that can raise blood pressure; researchers suspect it may also damage cells that produce too much of the hormone in some adrenal gland tumours.
Researchers caution that the finding comes from a small group and that a larger study is under way to test whether the effect is common and persistent.

Summary written by Lux AI from 2 articles

Key facts

Patients in follow-up: 14
Continued treatment: Six to 12 months
Reported sustained effect: Lower blood pressure for up to two years after stopping
Primary aldosteronism share of cases: Five to 10 per cent of high blood pressure cases
Next research step: A larger study is under way